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The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions.

作者信息

Herman M A, Horvitz H R

机构信息

Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139.

出版信息

Development. 1994 May;120(5):1035-47. doi: 10.1242/dev.120.5.1035.

DOI:10.1242/dev.120.5.1035
PMID:8026318
Abstract

The generation and orientation of cellular and organismic polarity are fundamental aspects of development. Mutations in the gene lin-44 of the nematode Caenorhabditis elegans reverse both the relative positions of specific sister cells and the apparent polarities of these cells. Thus, lin-44 mutants appear to generate polar cells but to misorient these cells along the body axis of the animal. We postulate that lin-44 acts to specify the orientation of polar cells.

摘要

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