尼日利亚非洲人特发性帕金森病中的外源物质代谢

Xenobiotic metabolism in idiopathic Parkinson's disease in Nigerian Africans.

作者信息

Igbokwe E, Ogunniyi A O, Osuntokun B O

机构信息

Department of Medicine, University of Ibadan, Nigeria.

出版信息

East Afr Med J. 1993 Dec;70(12):807-9.

PMID:8026358

Abstract

The acetylator phenotype using sulphadimidine as a probe drug was studied in 20 idiopathic Parkinson's disease (IPD) patients and 21 control subjects. 10(50%) of the IPD patients belonged to the slow acetylator phenotype but this did not differ significantly from the proportion 7 (33%) of control subjects who were slow acetylators. The result does not suggest a role for acetylation in the aetiopathogenesis of IPD in Nigerian African.

摘要

以磺胺二甲嘧啶作为探针药物，对20例特发性帕金森病（IPD）患者和21名对照者的乙酰化表型进行了研究。10名（50%）IPD患者属于慢乙酰化表型，但这与7名（33%）为慢乙酰化表型的对照者比例无显著差异。该结果并不提示乙酰化在尼日利亚非洲人IPD病因发病机制中起作用。