Nathan D H, Sieff C A
Gematol Transfuziol. 1994 Mar-Apr;39(2):3-10.
Hematopoiesis is regulated by a tiny population of cells, the stem cells and committed progenitors. These cells are under the influence of hematopoietic growth factors most of which are produced immediately in their environments. Their fates are strongly influenced by those growth factors. The growth factors interact with specific receptors that are present on progenitor surfaces and may in fact induce changes in the levels of those receptors. The receptors form dimers or heterodimers to pass proliferative and differentiation signals into the cell. We do not yet know exactly how that signalling is accomplished, but will probably known much more about it in the next year or so.
造血作用由一小群细胞调控，即干细胞和定向祖细胞。这些细胞受到造血生长因子的影响，其中大多数生长因子是在其所处环境中即时产生的。它们的命运受到这些生长因子的强烈影响。生长因子与祖细胞表面存在的特定受体相互作用，实际上可能会诱导这些受体水平的变化。这些受体形成二聚体或异二聚体，将增殖和分化信号传递到细胞内。我们目前还不完全清楚这种信号传导是如何完成的，但在未来一年左右可能会对此有更多了解。
