Changes in ovulatory and steroidogenic responses in mice after administration of the ribosome inactivating proteins momorcochin, luffaculin and luffins.
作者信息
Ng T B, Chan W Y, Yeung H W
机构信息
Department of Biochemistry, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N.T.
出版信息
Gen Pharmacol. 1994 Jan;25(1):19-21. doi: 10.1016/0306-3623(94)90005-1.
Immature mice were induced to ovulate by pregnant serum gonadotropin and human chorionic gonadotropin. 2. The ribosome inactivating proteins luffaculin, luffin-a, luffin-b and momorcochin were administered i.p. 3. It was found that all four ribosome inactivating proteins elicited a reduction in the circulating titer of estradiol-17 beta. 4. Both luffaculin and momorcochin brought about an increase in the number of degenerated oocytes. 5. Only momorcochin caused a decrease in the ovarian weight and the number of ovulated oocytes.