氯丙嗪诱导红细胞肿胀的机制。

The mechanism of chlorpromazine-induced red blood cell swelling.

Cornelius A S, Reilly M P, Suzuki M, Asakura T, Horiuchi K

Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine 19104.

Gen Pharmacol. 1994 Jan;25(1):205-10. doi: 10.1016/0306-3623(94)90034-5.

Abstract

Chlorpromazine (CPZ)-induced red blood cell (RBC) swelling was investigated by determination of electrolyte, mean cell volume (MCV) and water content changes in CPZ-treated cells. 2. CPZ-induced RBC swelling is dose-, hematocrit- and pH-dependent, and is associated with a net increase in RBC monovalent cation and Cl- contents. 3. The partition coefficient (Kp) for the CPZ-RBC membrane interaction is pH dependent (Kp = 2500 at pH 7.8; Kp = 840 at pH 6.8). 4. Despite the pH dependence of Kp values an equal number of CPZ molecules is required to induce a 12% increase in MCV at pH 7.8 and 6.8.

摘要

通过测定经氯丙嗪（CPZ）处理的细胞中的电解质、平均细胞体积（MCV）和含水量变化，研究了氯丙嗪（CPZ）诱导的红细胞（RBC）肿胀。2. CPZ诱导的RBC肿胀具有剂量、血细胞比容和pH依赖性，并且与RBC单价阳离子和Cl-含量的净增加有关。3. CPZ与RBC膜相互作用的分配系数（Kp）取决于pH（在pH 7.8时Kp = 2500；在pH 6.8时Kp = 840）。4. 尽管Kp值具有pH依赖性，但在pH 7.8和6.8时，诱导MCV增加12%所需的CPZ分子数量相等。