编码人丝虫寄生虫盘尾丝虫假定烟碱型乙酰胆碱受体亚基的cDNA的克隆
Cloning of a cDNA encoding a putative nicotinic acetylcholine receptor subunit of the human filarial parasite Onchocerca volvulus.
作者信息
Ajuh P M, Egwang T G
机构信息
Department of Filarial Molecular Biology, Centre International de Recherches Médicales de Franceville, Gabon.
出版信息
Gene. 1994 Jun 24;144(1):127-9. doi: 10.1016/0378-1119(94)90216-x.
A partial cDNA clone encoding a putative nicotinic acetylcholine receptor (ACHR) subunit of the human filarial parasite, Onchocerca volvulus, has been isolated and sequenced. A truncated open reading frame of 1308 bp capable of encoding 436 amino acids with a calculated M(r) of 51,209 was identified. The absence of the double cysteine residues necessary for neurotransmitter binding indicates that the cloned ACHR is a non-alpha subunit.
已分离并测序了一个编码人丝虫寄生虫盘尾丝虫假定烟碱型乙酰胆碱受体（ACHR）亚基的部分cDNA克隆。鉴定出一个1308 bp的截短开放阅读框，其能够编码436个氨基酸，计算的分子量为51,209。缺乏神经递质结合所需的双半胱氨酸残基表明克隆的ACHR是非α亚基。
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