小鼠体内骨科植入物致癌性和慢性毒性的评估。

Evaluation of carcinogenicity and chronic toxicity associated with orthopedic implants in mice.

作者信息

Takamura K, Hayashi K, Ishinishi N, Yamada T, Sugioka Y

机构信息

Department of Orthopaedic Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

J Biomed Mater Res. 1994 May;28(5):583-9. doi: 10.1002/jbm.820280508.

DOI:10.1002/jbm.820280508

PMID:8027098

Abstract

The carcinogenicity and chronic toxicity of 316L stainless steel, nickel, Ti-6A1-4V, hydroxyapatite (HA)-coated Ti-6A1-4V, aluminum oxide containing yttrium oxide, and zirconium oxide containing yttrium oxide were evaluated by implanting solid rods of each material in the thigh muscle of C57BL/6N mice for 24 months. Nickel alloy showed high carcinogenic and toxic potencies, whereas other materials showed no evidence of them. Tumors retaining nickel alloys were malignant fibrous histiocytoma or fibrosarcoma. In some cases, lymphomata that seemed to develop spontaneously were found around the implants because lymphocytes were known to accumulate in chronic inflammatory lesions, and this phenomenon also might be applied to lymphoma.

摘要

通过将每种材料的实心棒植入C57BL/6N小鼠大腿肌肉中24个月，评估了316L不锈钢、镍、Ti-6A1-4V、羟基磷灰石（HA）涂层的Ti-6A1-4V、含氧化钇的氧化铝和含氧化钇的氧化锆的致癌性和慢性毒性。镍合金显示出高致癌性和毒性，而其他材料则未显示出此类迹象。含有镍合金的肿瘤为恶性纤维组织细胞瘤或纤维肉瘤。在某些情况下，由于已知淋巴细胞会在慢性炎症病变中积聚，在植入物周围发现了似乎是自发形成的淋巴瘤，这种现象也可能适用于淋巴瘤。