Takahashi M, Saitoh K, Ohta K, Kudoh Y
Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Kansenshogaku Zasshi. 1994 Apr;68(4):467-73. doi: 10.11150/kansenshogakuzasshi1970.68.467.
The association between Campylobacter jejuni infection and Guillain-Barré Syndrome (GBS) was investigated serologically in 52 GBS patients. The specific antibody titers of immunoglobulin G class to C. jejuni were measured in the patient' sera using an enzyme-linked immunosorbent assay with acid-extracted antigen. The analysis showed that 31 (59.6%) of the 52 patients had evidences of recent C. jejuni infections in contrast to 16 (8.9%) of 180 healthy persons. The seropositive patients were analyzed with respect to the nature of their anticedent events. C. jejuni antibodies were found in 22 (75.9%) of the 29 patients with diarrhea, one patient with esophagus cancer, 4 (30.8%) of the 13 patients with upper respiratory infections, and 4 (50.0%) of the 8 patients without any symptoms, respectively. These findings support that there may be a close relationship between C. jejuni infection and the GBS with preceding diarrhea.
对52例吉兰-巴雷综合征（GBS）患者进行血清学研究，以调查空肠弯曲菌感染与GBS之间的关联。采用酸提取抗原的酶联免疫吸附试验检测患者血清中针对空肠弯曲菌的免疫球蛋白G类特异性抗体滴度。分析显示，52例患者中有31例（59.6%）有近期空肠弯曲菌感染的证据，相比之下，180名健康人中有16例（8.9%）有该感染证据。对血清阳性患者的前驱事件性质进行了分析。在29例腹泻患者中有22例（75.9%）、1例食管癌患者、13例上呼吸道感染患者中有4例（30.8%）、8例无任何症状的患者中有4例（50.0%）检测到空肠弯曲菌抗体。这些发现支持空肠弯曲菌感染与伴有前驱腹泻的GBS之间可能存在密切关系。
