Rahal P S, Cornelius V
University of Louisville, Department of Medicine, School of Medicine, KY.
J Ky Med Assoc. 1994 May;92(5):183-7.
Two malignancies in one patient was a remote possibility in the distant past, but currently more of these cases are being seen. At our institution, several patients with Chronic Lymphocytic Leukemia (CLL) were seen to develop oat cell carcinoma of the lung. The decreased immunity and B-cell dysfunction in CLL probably accounts for this secondary malignancy. We are presenting these cases to alert physicians of combined malignancies in a patient with increased aggressiveness of oat cell carcinoma.
在过去,同一患者身上出现两种恶性肿瘤的可能性微乎其微,但目前这类病例越来越常见。在我们机构,有几位慢性淋巴细胞白血病(CLL)患者被发现患上了肺燕麦细胞癌。CLL患者免疫力下降和B细胞功能障碍可能是导致这种继发性恶性肿瘤的原因。我们展示这些病例是为了提醒医生注意燕麦细胞癌侵袭性增加的患者可能合并存在恶性肿瘤。