Rodrigo Angulo M L, Fernández Sánchez B, Rodríguez-Echandía E L
Cell Tissue Res. 1978 Aug 25;192(1):67-76. doi: 10.1007/BF00231023.
It is believed that differentiation and maintenance of taste buds in vertebrates is dependent on the trophic function of their sensory nerve supply. In the present work, colchicine was injected into the circumvallate papilla of the rat. This produced a reversible blockade of neuroplasmic transport and disappearance of taste buds. Colchicine inhibited the further differentiation of bud cells, but apparently did not change the life cycle of the cells present already at the time of injection. It is speculated that the neurotrophic factors in this particular cell system are effective to induce cell differentiation only.
人们认为，脊椎动物味蕾的分化和维持依赖于其感觉神经供应的营养功能。在本研究中，将秋水仙碱注射到大鼠的轮廓乳头中。这导致了神经浆运输的可逆性阻断和味蕾消失。秋水仙碱抑制了味蕾细胞的进一步分化，但显然没有改变注射时已存在细胞的生命周期。据推测，在这个特定细胞系统中的神经营养因子仅对诱导细胞分化有效。
