Ikehara S
First Department of Pathology, Kansai Medical University.
Rinsho Ketsueki. 1994 May;35(5):446-53.
We describe here characteristics of animal models for intractable hematologic disorders and discuss the concept of "stem cell disorders." Using these animal models, we have found that bone marrow transplantation can be used to treat both systemic and organ-specific autoimmune diseases, and that transplantation of hematopoietic stem cells from autoimmune-prone mice induces autoimmune diseases in normal mice. Based on these findings, we have proposed that autoimmune diseases are stem cell disorders. It has recently been reported that bone marrow transplantation can be used to treat autoimmune diseases such as rheumatoid arthritis and ulcerative colitis, also in humans.
我们在此描述难治性血液系统疾病动物模型的特征，并讨论“干细胞疾病”的概念。利用这些动物模型，我们发现骨髓移植可用于治疗全身性和器官特异性自身免疫性疾病，并且来自易患自身免疫性疾病小鼠的造血干细胞移植可在正常小鼠中诱发自身免疫性疾病。基于这些发现，我们提出自身免疫性疾病是干细胞疾病。最近有报道称，骨髓移植在人类中也可用于治疗类风湿性关节炎和溃疡性结肠炎等自身免疫性疾病。
