Kanegae K, Itoh K, Kato C, Nagao K, Nakada K, Fujimori K, Furudate M
Department of Nuclear Medicine, Hokkaido University, School of Medicine.
Kaku Igaku. 1994 May;31(5):441-9.
201Tl/99mTc subtraction scintigraphy (TTS) has been recognized as a useful procedure in the preoperative localization of hyperfunctioning parathyroid glands. Ninety-one patients suspected of hyperparathyroidism (HPT) were studied with TTS for the localization of lesions and 59 patients out of those had a neck exploration and parathyroidectomy which allowed for clinical correlation of pathologic findings with the imaging results. The weight of 30 glands of adenoma ranged 0.100 to 11.700 g (1.840 +/- 0.446 g (mean +/- SE)). The weight of 88 glands of hyperplasia ranged 0.025 to 7.000 g (0.623 +/- 0.100 g). Overall sensitivity and specificity were 47% and 54%, respectively. The sensitivity for the adenoma and the hyperplasia was 87% and 33%, respectively. The specificity for them was 57% and 52%. There was significant difference for the detection between adenomas and hyperplasias. TTS is more useful for the localizing diagnosis of parathyroid adenomas than parathyroid hyperplasia in a patient with hyperfunctioning parathyroid state.
201铊/99锝减影闪烁扫描术（TTS）已被公认为是一种用于术前定位功能亢进甲状旁腺的有用方法。对91例疑似甲状旁腺功能亢进（HPT）的患者进行了TTS检查以定位病变，其中59例患者接受了颈部探查和甲状旁腺切除术，从而可以将病理结果与影像学结果进行临床对比。30个腺瘤样腺体的重量在0.100至11.700克之间（1.840±0.446克（平均值±标准误））。88个增生样腺体的重量在0.025至7.000克之间（0.623±0.100克）。总体敏感性和特异性分别为47%和54%。腺瘤和增生的敏感性分别为87%和33%。它们的特异性分别为57%和52%。腺瘤和增生之间的检测存在显著差异。在甲状旁腺功能亢进状态的患者中，TTS对甲状旁腺腺瘤的定位诊断比对甲状旁腺增生更有用。
