Milicević Z, Jelaković B, Marinković M
Zavod za nefrologiju i arterijsku hipertenziju Klinike za unutarnje bolesti KBC i Mediciniskog fakulteta Sveucilista u Zagrebu.
Lijec Vjesn. 1994 Jan-Feb;116(1-2):14-7.
The frequency of hyperuricemia in 253 patients with essential hypertension (EH) was studied. The level of uric acid in serum and frequency of hyperuricemia were determined in patients divided according to sex and renin plasma activity (RPA). High values of uric acid in serum were found in a total of 69 patients (27.3%), of which there were 40 males (30.1%) and 29 females (24.2%). The highest values of uric acid were found in those with high RPA, but the difference was significant only in males (p < 0.05). No correlation was observed between the values of the uric acid in serum and RPA in none of the renin subgroups. On the basis of our study, it was not possible to explain the high values of uric acid in serum in patients with EH, especially in those with high plasma renin activity, as well as the role of renin-angiotensin-aldosterone system in the pathogenesis of hyperuricemia.
对253例原发性高血压（EH）患者的高尿酸血症发生率进行了研究。根据性别和血浆肾素活性（RPA）对患者进行分组，测定其血清尿酸水平和高尿酸血症发生率。共有69例患者（27.3%）血清尿酸值较高，其中男性40例（30.1%），女性29例（24.2%）。尿酸值最高的是RPA高的患者，但仅在男性中差异有统计学意义（p<0.05）。在任何一个肾素亚组中，均未观察到血清尿酸值与RPA之间存在相关性。根据我们的研究，无法解释EH患者血清尿酸值升高的原因，尤其是血浆肾素活性高的患者，也无法解释肾素-血管紧张素-醛固酮系统在高尿酸血症发病机制中的作用。
