Hunter B E, de Fiebre C M, Papke R L, Kem W R, Meyer E M
Department of Neuroscience, University of Florida College of Medicine, Gainesville 32601.
Neurosci Lett. 1994 Feb 28;168(1-2):130-4. doi: 10.1016/0304-3940(94)90433-2.
Long-term potentiation (LTP) can be modulated by a number of neurotransmitter receptors including muscarinic and GABAergic receptor types. We have found that a novel nicotinic agonist, 2,4-dimethoxybenzylidene anabaseine (DMXB), facilitated the induction of LTP in the hippocampus in a dose-dependent and mecamylamine-sensitive manner. DMXB displaced high affinity nicotinic [125I]alpha-bungarotoxin and [3H]acetylcholine binding in rat brain. Xenopus oocyte studies demonstrated that DMXB has agonist activity at alpha 7 but not alpha 4/beta 2 nicotinic receptor subtypes. These results indicated that DMXB is a novel nicotinic agonist with apparent specificity for the alpha 7/alpha-bungarotoxin nicotinic receptor subtype and indicate that nicotinic receptor activation is capable of modulating the induction of long-term potentiation.
长时程增强（LTP）可被多种神经递质受体调节，包括毒蕈碱型和γ-氨基丁酸能受体类型。我们发现一种新型烟碱激动剂2,4-二甲氧基亚苄基假木贼碱（DMXB），以剂量依赖性和对美加明敏感的方式促进海马体中LTP的诱导。DMXB取代了大鼠脑中高亲和力烟碱型[125I]α-银环蛇毒素和[3H]乙酰胆碱的结合。非洲爪蟾卵母细胞研究表明，DMXB对α7烟碱受体亚型具有激动剂活性，但对α4/β2烟碱受体亚型无激动剂活性。这些结果表明，DMXB是一种对α7/α-银环蛇毒素烟碱受体亚型具有明显特异性的新型烟碱激动剂，并表明烟碱受体激活能够调节长时程增强的诱导。
