Smith D H, Lowenstein D H, Gennarelli T A, McIntosh T K
Division of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104-6316.
Neurosci Lett. 1994 Feb 28;168(1-2):151-4. doi: 10.1016/0304-3940(94)90438-3.
Memory dysfunction following head injury is a prominent feature in humans, yet the biological basis of this abnormality remains unknown. Following parasagittal fluid-percussion (FP) brain injury in the rat, we have previously observed profound spatial memory dysfunction relatively soon following injury (i.e. at 42 h). In the present study, we show that this memory dysfunction persists for at least 2 weeks following FP brain injury, and that it is associated with a selective bilateral loss of neurons in the dentate hilar region of the hippocampus. Given the important role of the hippocampus in memory, these observations may provide a potential anatomic substrate to explain, in part, the development posttraumatic memory deficits.
头部受伤后的记忆功能障碍是人类的一个突出特征，然而这种异常的生物学基础仍然未知。在大鼠矢状旁流体冲击（FP）脑损伤后，我们之前观察到损伤后相对较快（即42小时）就出现了严重的空间记忆功能障碍。在本研究中，我们表明这种记忆功能障碍在FP脑损伤后至少持续2周，并且它与海马齿状回门区神经元的选择性双侧缺失有关。鉴于海马体在记忆中的重要作用，这些观察结果可能提供一个潜在的解剖学基础，以部分解释创伤后记忆缺陷的发生。
