López Costa J J, Averill S, Saavedra J P, Priestley J V
Department of Physiology, UMDS St Thomas's Hospital, London, UK.
Neurosci Lett. 1994 Feb 28;168(1-2):167-71. doi: 10.1016/0304-3940(94)90442-1.
Light and electron microscopic immunocytochemistry was used to examine the serotonin (5-HT) innervation of the rat spinal trigeminal subnucleus caudalis. 5-HT-immunoreactive fibres form a dense plexus in lamina I and outer lamina II and synapse with the cell bodies and proximal dendrites of local neurones. Light microscopic double labelling revealed that the 5-HT axons contact enkephalin immunoreactive neurones in both laminae. The 5-fHT electron microscopic results indicate that at least some of these contacts are likely to be synapses. 5-HT axons are therefore in a position to exert a direct action on enkephalinergic interneurones and this may contribute to the analgesic actions of the 5-HT system.
运用光镜和电镜免疫细胞化学技术研究大鼠三叉神经脊束核尾侧亚核的5-羟色胺（5-HT）神经支配情况。5-HT免疫反应性纤维在I层和II层外层形成密集的神经丛，并与局部神经元的胞体和近端树突形成突触。光镜双重标记显示，5-HT轴突在这两层中均与脑啡肽免疫反应性神经元相接触。5-HT电镜结果表明，这些接触中至少有一些可能是突触。因此，5-HT轴突能够对脑啡肽能中间神经元产生直接作用，这可能有助于5-HT系统的镇痛作用。
