Radkowski M, Kopicz-Kamińska E, Laskus T, Rogers S, Babiuch L, Slusarczyk J
Zakład Immunopatologii, Instytut Chorób Zakaźnych i Pasozytniczych Akademii Medycznej, Warszawie.
Pol Arch Med Wewn. 1994 Mar;91(3):201-5.
Serum soluble interleukin 2 receptor (sIL-2R) concentration and the percentage of lymphocytes presenting this receptor (CD25+) were investigated in 28 asymptomatic HIV carriers or patients with lymphadenopathy only and in 15 AIDS patients. The levels of sIL-2R were found to be higher in AIDS patients (mean 1060 U/ml) than in persons during the initial stages of infection (mean 750 U/ml) or controls (mean 470 U/ml). No significant differences in the quantity of CD25+ lymphocytes between these groups were observed, with the means of 1.0; 1.3 and 1.1, respectively. However, a decrease in percentage of these cells were found in patients with advanced HIV infection. Since sIL-2R is regarded as a marker of immune system activation its detection could be helpful in the assessment of the immune status impairment in HIV infected patients.
对28名无症状HIV携带者或仅有淋巴结病的患者以及15名艾滋病患者的血清可溶性白细胞介素2受体（sIL-2R）浓度和表达该受体的淋巴细胞百分比（CD25+）进行了研究。发现艾滋病患者的sIL-2R水平（平均1060 U/ml）高于感染初期的人（平均750 U/ml）或对照组（平均470 U/ml）。这些组之间CD25+淋巴细胞数量没有显著差异，平均值分别为1.0、1.3和1.1。然而，在晚期HIV感染患者中发现这些细胞的百分比有所下降。由于sIL-2R被视为免疫系统激活的标志物，其检测有助于评估HIV感染患者的免疫状态损害。
