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血浆置换联合环磷酰胺成功治疗狼疮性肾炎伴肾病综合征

[Lupus nephritis with nephrotic syndrome successfully treated with plasmapheresis and cyclophosphamide].

作者信息

Obroniecka I, Korsak J, Wańkowicz Z

机构信息

Kliniki Nefrologii IMW CSK WAM.

出版信息

Pol Arch Med Wewn. 1994 Mar;91(3):227-31.

PMID:8029131
Abstract

In a 45 years woman with advanced nephrotic syndrome in the course of SLE IgM nephropathy, transient renal failure made the continuation of the conventional steroid therapy impossible. Applied as a saving life therapy, plasmapheresis followed by i.v. pulses of cyclophosphamide, caused resolution of lupus nephritis. Since the withdrawal of cyclophosphamide, the patient has been observed for 18 month, showing no evidence of recurrence of lupus nephritis.

摘要

在一名患有系统性红斑狼疮IgM肾病且处于晚期肾病综合征的45岁女性患者中,短暂性肾衰竭使得无法继续进行常规类固醇治疗。作为挽救生命的疗法,采用了血浆置换术,随后静脉注射环磷酰胺脉冲疗法,结果狼疮性肾炎得到缓解。自停用环磷酰胺以来,对该患者进行了18个月的观察,未发现狼疮性肾炎复发的迹象。

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