Bartoletti M, Gaiardi M, Gubellini C, Bacchi A, Babbini M
Department of Pharmacology, University of Bologna, Italy.
Pharmacol Biochem Behav. 1994 Apr;47(4):969-72. doi: 10.1016/0091-3057(94)90305-0.
The effects of various doses of morphine (0, 1.25, 2.5, 5 mg/kg) and clonidine (0, 1.67, 15, 45 micrograms/kg) on motility were determined in food satiated and in food deprived rats. Food deprivation failed to change the general activity of rats after saline injections. Nevertheless, food-deprived animals tested under morphine were more active than food satiated ones. Clonidine exhibited slight psychomotor stimulant properties that were not increased by food deprivation. The results are discussed in terms of possible mechanisms of deprivation-related hypermotility.
在饱腹和饥饿的大鼠中测定了不同剂量的吗啡（0、1.25、2.5、5毫克/千克）和可乐定（0、1.67、15、45微克/千克）对运动能力的影响。饥饿并未改变注射生理盐水后大鼠的一般活动。然而，在吗啡作用下测试的饥饿动物比饱腹动物更活跃。可乐定表现出轻微的精神运动兴奋特性，饥饿并未增强这种特性。根据与饥饿相关的运动亢进的可能机制对结果进行了讨论。
