Effects of cocaine on fixed-interval behavior and schedule-induced alcohol consumption in male and female rats.

Three male and three female Wistar rats pressed a lever on a fixed-interval 60-s schedule of food reinforcement while they had simultaneous access to an alcohol solution. They were challenged with different doses of cocaine hydrochloride (vehicle, 1, 3, 10, and 30 mg/kg) once lever press rates and lick rates had stabilized. Low doses of cocaine (1 and 3 mg/kg) did not systematically affect lever press rates or lick rates. The administration of 10 and 30 mg/kg cocaine dose-dependently decreased lever press rates and schedule-induced licking to a greater extent in female than in male rats. Lick rates decreased even when cocaine administration did not affect the number of pellets obtained during an experimental session. Lever press rates accelerated throughout the interreinforcement interval during control sessions. Licking was mostly limited to the first 10 s (males) or 20 s (females) after pellet presentation. Cocaine administration did not affect the distribution of lever presses and licks during the interreinforcement interval. The results of the present experiment extend previous observations that cocaine's rate-dependent effects on lever press rates may be limited to situations in which changes in lever press frequency and/or distribution negatively affect reinforcement frequency and/or the physiological consequences of schedule-induced behavior.