Islam A K, Dougherty T, Koch J E, Bodnar R J
Department of Psychology, Queens College, City University of New York, Flushing 11367.
Pharmacol Biochem Behav. 1994 May;48(1):193-201. doi: 10.1016/0091-3057(94)90516-9.
Functional interactions between serotonergic (5-HT) and opioid drugs have been observed with 5-HT3 receptor antagonism enhancing the inhibitory actions of naloxone and naltrexone in both food-deprived and glucoprivic rats; 5-HT2A/C receptor antagonism enhanced naltrexone's inhibition of insulin hyperphagia. The present study examined whether pretreatment with either general 5-HT (methysergide: 0.5-5 mg/kg), 5-HT2A/C (ritanserin: 0.25-2.5 mg/kg), or 5-HT3 (ICS 205930: 0.5-5 mg/kg) antagonists altered the pattern and magnitude of ad lib intake of simple (sucrose: 10%) or more complex (maltose dextrin: MD, 10%) carbohydrate solutions, or naltrexone's (0.25-2.5 mg/kg) inhibition of these forms of intake. Methysergide significantly increased the pattern and magnitude of sucrose intake at low (0.5-2.5 mg/kg) doses, and transiently delayed the pattern of MD intake at high (5 mg/kg) doses. Ritanserin significantly accelerated the pattern, but not the magnitude of sucrose intake at low (0.25-1.25 mg/kg) doses without affecting MD intake. ICS 205930 reduced the magnitude of sucrose intake at the highest (5 mg/kg) dose, and transiently reduced MD intake. Naltrexone dose dependently altered the pattern and magnitude of both sucrose and MD intake. Coadministration of ritanserin and naltrexone either eliminated or delayed the pattern of opioid antagonist inhibition of both sucrose and MD intake. Methysergide and ICS 205930 pretreatment produced minor changes in the pattern of naltrexone-induced inhibition. These data indicate that 5-HT receptor differentially modulate the pattern of carbohydrate intake, and indicate differential ingestive interactions between 5-HT and opioid antagonists under challenge and palatable conditions.
已观察到血清素能（5-羟色胺，5-HT）与阿片类药物之间的功能相互作用，5-HT3受体拮抗作用增强了纳洛酮和纳曲酮对饥饿和糖缺乏大鼠的抑制作用；5-HT2A/C受体拮抗作用增强了纳曲酮对胰岛素性多食的抑制作用。本研究考察了用一般的5-HT（麦角新碱：0.5-5mg/kg）、5-HT2A/C（利坦色林：0.25-2.5mg/kg）或5-HT3（ICS 205930：0.5-5mg/kg）拮抗剂预处理是否会改变简单（蔗糖：10%）或更复杂（麦芽糖糊精：MD，10%）碳水化合物溶液随意摄入量的模式和幅度，或纳曲酮（0.25-2.5mg/kg）对这些摄入形式的抑制作用。麦角新碱在低剂量（0.5-2.5mg/kg）时显著增加了蔗糖摄入的模式和幅度，在高剂量（5mg/kg）时短暂延迟了MD摄入的模式。利坦色林在低剂量（0.25-1.25mg/kg）时显著加快了蔗糖摄入的模式，但未影响幅度，且不影响MD摄入。ICS 205930在最高剂量（5mg/kg）时降低了蔗糖摄入的幅度，并短暂降低了MD摄入。纳曲酮剂量依赖性地改变了蔗糖和MD摄入的模式和幅度。利坦色林与纳曲酮联合给药消除或延迟了阿片类拮抗剂对蔗糖和MD摄入的抑制模式。麦角新碱和ICS 205930预处理在纳曲酮诱导的抑制模式上产生了微小变化。这些数据表明5-HT受体对碳水化合物摄入模式有不同调节作用，并表明在激发和美味条件下5-HT与阿片类拮抗剂之间存在不同的摄入相互作用。
