Cogan E
Clinique de Médecine Interne Générale, Hôpital Brugmann, Bruxelles.
Rev Med Brux. 1994 Mar-Apr;15(2):55-60.
Hypereosinophilia may be associated with various clinical disorders. The severity of hypereosinophilia may be related to the underlying disease or to the possible deleterious effects of the eosinophils infiltrating most of the tissues, particularly the heart and the nervous system. Adverse reactions to drugs or other immunoallergic disorders are most often encountered. Among the parasitic diseases, helminthic infestations are especially incriminated. Cancers, autoimmune diseases and some T lymphoproliferative disorders represent the other reported conditions associated with hypereosinophilia. The detection of interleukin-5 (the most important cytokine involved in the control of eosinophils production and maturation) may contribute to the knowledge of some pathological hypereosinophilic disorders. In the absence of a well defined responsible factor, the idiopathic hypereosinophilic syndrome will be considered. The pathogenic role of a T lymphocyte disorder need to be considered in some cases.
嗜酸性粒细胞增多症可能与多种临床疾病相关。嗜酸性粒细胞增多症的严重程度可能与潜在疾病有关，也可能与嗜酸性粒细胞浸润大多数组织（尤其是心脏和神经系统）可能产生的有害影响有关。最常遇到的是药物不良反应或其他免疫过敏疾病。在寄生虫病中，蠕虫感染尤其受到怀疑。癌症、自身免疫性疾病和一些T淋巴细胞增殖性疾病是其他报道的与嗜酸性粒细胞增多症相关的疾病。白细胞介素-5（参与控制嗜酸性粒细胞产生和成熟的最重要细胞因子）的检测可能有助于了解某些病理性嗜酸性粒细胞增多症。在没有明确的致病因素的情况下，将考虑特发性嗜酸性粒细胞增多综合征。在某些情况下，需要考虑T淋巴细胞疾病的致病作用。
