[儿童非霍奇金淋巴瘤：Ⅲ期患者的治疗结果]
[Non-Hodgkin's lymphomas in childhood: results of treatment in patients in stage III].
作者信息
Maluf Júnior P T, Britto J L, Cristofani L, Almeida M T, Odone Filho V
机构信息
Unidade de Onco-Hematologia do Instituto da Criança Prof. Pedro de Alcantara, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo.
出版信息
Rev Hosp Clin Fac Med Sao Paulo. 1993 Nov-Dec;48(6):278-82.
From January 1980 to December 1984, 22 children with non-Hodgkin's lymphoma were admitted to the "Instituto da Criança-HCFMUPS" and according to the LNH-I-80 Protocol including a remission induction phase (Cyclofosfamide day 1, Vincristine days 3, 10, 17, 24, Daunomycin days 12 and 13, Prednisone for 30 days), followed by a continuation phase (Cyclofosfamide x 7 days + Adriamycin day 8 ARA-C x 4 days + Vincristine day 5, Mercaptopurine x 4 days + Methotrexate day 5) alternating three pairs of drugs during 72 weeks. Mercaptopurine and Methotrexate given during additional 48 weeks completes therapy. Twenty-one out of 22 patients attained complete remission. One patient died after widespread infection. Six relapses occurred, five of them in Burkitt's lymphoma patients. Although highly effective in the non-Burkitt's patients, the LNH-I-80 Protocol failed in keeping Burkitt's patients in event free survival.
1980年1月至1984年12月，22名非霍奇金淋巴瘤患儿被收治于“儿童研究所 - 南大河联邦大学医学院附属医院”，并按照LNH - I - 80方案进行治疗，该方案包括一个缓解诱导期（环磷酰胺第1天、长春新碱第3、10、17、24天、柔红霉素第12和13天、泼尼松使用30天），随后是一个延续期（环磷酰胺使用7天 + 阿霉素第8天、阿糖胞苷使用4天 + 长春新碱第5天、巯嘌呤使用4天 + 甲氨蝶呤第5天），在72周内交替使用三对药物。巯嘌呤和甲氨蝶呤在额外的48周内使用以完成治疗。22名患者中有21名实现完全缓解。1名患者在发生广泛感染后死亡。出现6例复发，其中5例发生在伯基特淋巴瘤患者中。尽管LNH - I - 80方案对非伯基特淋巴瘤患者非常有效，但未能使伯基特淋巴瘤患者实现无事件生存。
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