泰-萨克斯病：在非犹太人群体中的高基因频率。
Tay-Sachs disease: high gene frequency in a non-Jewish population.
作者信息
Kelly T E, Chase G A, Kaback M M, Kumor K, McKusick V A
机构信息
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
出版信息
Am J Hum Genet. 1975 May;27(3):287-91.
Abstract
A non-Amish "Pennsylvania Dutch" semi-isolate was found to have a high frequency of Tay-Sachs gene. This high frequency could be ascribed to founder effect and may represent, in microcosm, how this mechanism could have produced the high gene frequency among Ashkenazi Jews.
摘要
人们发现，一个非阿米什人的“宾夕法尼亚荷兰人”半隔离群体中，泰-萨克斯基因的频率很高。这种高频率可能归因于奠基者效应，并且在微观层面上可能代表了这种机制如何在德系犹太人中产生高基因频率的。
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本文引用的文献
1
THE DISTRIBUTION OF CERTAIN GENES IN THE OLD ORDER AMISH.
Cold Spring Harb Symp Quant Biol. 1964;29:99-114. doi: 10.1101/sqb.1964.029.01.015.
2
Population dynamics of Tay-Sachs disease. I. Reproductive fitness and selection.泰-萨克斯病的种群动态。I. 生殖适合度与选择
Am J Hum Genet. 1966 Jul;18(4):313-27.
3
Controversy in human genetics: founder effect in Tay-Sachs disease.人类遗传学中的争议：泰-萨克斯病的奠基者效应。
Am J Hum Genet. 1972 May;24(3):339-40.
4
Founder effect in Tay-Sachs disease.泰-萨克斯病中的奠基者效应。
Am J Hum Genet. 1973 Jan;25(1):108.
5
Approaches to the control and prevention of Tay-Sachs disease.控制和预防泰-萨克斯病的方法。
Prog Med Genet. 1974;10:103-34.
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