家族相似性分析。IV. 分离分析的操作特征。
Analysis of family resemblance. IV. Operational characteristics of segregation analysis.
作者信息
MacLean C J, Morton N E, Lew R
机构信息
Population Genetics Laboratory, University of Hawaii, Honolulu 96822.
出版信息
Am J Hum Genet. 1975 May;27(3):365-84.
Abstract
In simulated data, segregation analysis of quantitative traits was found to be powerful for resolving a major locus from polygenic and cultural inheritance. It is reasonably robust against a variety of deviations from the model if and only if a major locus, polygenic heritability, and environment common to sibs are simultaneously included in the model, and heterogeneity tests among mating types are performed. Most of the information in quantitative data about a major locus is lost when reduced to affection status.
摘要
在模拟数据中，发现数量性状的分离分析对于从多基因和文化遗传中解析出主基因座很有效。当且仅当模型中同时包含主基因座、多基因遗传力以及同胞共有的环境，并且对交配类型进行异质性检验时，该方法对于各种偏离模型的情况具有一定的稳健性。当数量数据简化为患病状态时，关于主基因座的大部分信息都会丢失。
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