[人尿中卡鲁睾酮代谢产物的研究]
[Studies on urinary metabolites of calusterone in man].
作者信息
Zhang Y Z, Liu X, Zhang C J, Ye L
机构信息
National research Institute of Sports Medicine, Beijing.
出版信息
Yao Xue Xue Bao. 1993;28(12):918-23.
The metabolites of calusterone (17 beta-OH-7 beta, 17 alpha-dimethyl-androst-4-ene-3-one) in man has been investigated by GC/MS. After oral administration, the parent compound and seven metabolites were detected in the conjugated fraction. The extraction and fractionation of these metabolites were achieved by using XAD-2 column. The sample was derivatized with MSTFA/TMSI before GC/MS analysis. The mass spectra of the metabolites are presented and the metabolic pathway was discussed.
已通过气相色谱/质谱联用技术（GC/MS）对卡鲁睾酮（17β-羟基-7β,17α-二甲基-雄甾-4-烯-3-酮）在人体中的代谢产物进行了研究。口服给药后，在结合物部分检测到了母体化合物和七种代谢产物。这些代谢产物的提取和分离通过使用XAD-2柱来实现。在进行GC/MS分析之前，样品用N-甲基-N-(三甲基硅基)三氟乙酰胺/三甲基碘硅烷（MSTFA/TMSI）进行衍生化。给出了代谢产物的质谱图并讨论了代谢途径。
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