Yamamoto T, Ichien M, Suemori-Matsushita H, Kitazawa Y
Department of Ophthalmology, Gifu University School of Medicine, Japan.
Nippon Ganka Gakkai Zasshi. 1994 Jun;98(6):579-83.
We prospectively investigated the postoperative intraocular pressure (IOP) level, visual prognosis, and complications of trabeculectomy with adjunctive mitomycin C in normal-tension glaucoma. The subjects were 42 eyes of 29 patients who underwent surgery with 0.2 mg mitomycin C as an adjunct and were followed for 12-30 months (mean: 20.6 months). The preoperative IOP was 11-18 mmHg with a mean (+/- standard deviation) of 13.9 +/- 1.5 mmHg. The IOP decreased to 4-16 mmHg with a mean (+/- standard deviation) of 7.9 +/- 2.6 mmHg. The magnitude of the IOP reduction ranged from -1 to 10 mmHg with a mean of 6.0 mmHg. The number of eyes receiving ocular hypotensive medication decreased remarkably from 32 eyes preoperatively to 2 eyes postoperatively. The visual field deteriorated postoperatively in 2 eyes (4.8%) whose IOP was around 8 and 9 mmHg, respectively. Cataract progressed in 8 eyes (19.0%) and hypotonous maculopathy developed in 5 eyes (11.9%). Because the postoperative IOP level is close to the IOP value that is allegedly beneficial in preserving visual function in normal-tension glaucoma, the surgery is worth further consideration as a potent treatment for the disease.
我们前瞻性地研究了在正常眼压性青光眼中小梁切除术联合丝裂霉素C后的术后眼压水平、视觉预后及并发症。研究对象为29例患者的42只眼，这些患者接受了以0.2mg丝裂霉素C为辅助药物的手术，并随访了12 - 30个月（平均：20.6个月）。术前眼压为11 - 18mmHg，平均（±标准差）为13.9±1.5mmHg。术后眼压降至4 - 16mmHg，平均（±标准差）为7.9±2.6mmHg。眼压降低幅度为 - 1至10mmHg，平均为6.0mmHg。接受降眼压药物治疗的眼数从术前的32只眼显著减少至术后的2只眼。术后有2只眼（4.8%）视野恶化，其眼压分别约为8和9mmHg。8只眼（19.0%）发生白内障进展，5只眼（11.9%）发生低眼压性黄斑病变。由于术后眼压水平接近据称对正常眼压性青光眼视功能保护有益的眼压值，该手术作为该疾病的有效治疗方法值得进一步考虑。
