Davidsson L, Kastenmayer P, Hurrell R F
Nestlé Research Centre, Nestec Ltd, Lausanne, Switzerland.
Am J Clin Nutr. 1994 Aug;60(2):231-7. doi: 10.1093/ajcn/60.2.231.
The iron fortificant NaFeEDTA could have a potential negative effect on the metabolism of other minerals. We have used stable isotopes to monitor zinc and calcium metabolism in 10 women consuming a single meal of high-extraction wheat rolls (100 g flour) fortified with 5 mg Fe as either FeSO4 or NaFeEDTA. Six-day chemical balances were made simultaneously to study apparent zinc and calcium retention from the complete diet containing the differently iron-fortified breads (200 g flour; 10 mg added Fe/d). Mean 70Zn absorption from the bread meal increased from 20.9% with FeSO4 to 33.5% with NaFeEDTA (P < 0.05) whereas mean 44Ca absorption was 53.3% from both breads. When NaFeEDTA-fortified bread was consumed, there was a small but significant increase in urinary excretion of 70Zn and 44Ca. There was a similar small increase in urinary zinc excretion during the 6-d balance, although the apparent retention of zinc and calcium was not different. Thus, we found no negative overall effect of NaFeEDTA consumption on the metabolism of zinc and calcium. In contrast, the results suggest that NaFeEDTA added to low-bioavailability diets might increase zinc absorption as well as provide iron with high bioavailability.
铁强化剂乙二胺四乙酸铁钠（NaFeEDTA）可能会对其他矿物质的代谢产生潜在的负面影响。我们使用稳定同位素监测了10名女性的锌和钙代谢情况，这些女性食用了一餐用5毫克铁强化的高提取率小麦面包卷（100克面粉），铁源分别为硫酸亚铁（FeSO4）或乙二胺四乙酸铁钠（NaFeEDTA）。同时进行了为期6天的化学平衡研究，以探讨从含有不同铁强化面包（200克面粉；每天添加10毫克铁）的完整饮食中表观锌和钙的保留情况。面包餐中70Zn的平均吸收率从使用FeSO4时的20.9%增加到使用NaFeEDTA时的33.5%（P < 0.05），而两种面包中44Ca的平均吸收率均为53.3%。食用NaFeEDTA强化面包时，70Zn和44Ca的尿排泄量有小幅但显著的增加。在6天的平衡期内，尿锌排泄量也有类似的小幅增加，尽管锌和钙表观保留量没有差异。因此，我们发现食用NaFeEDTA对锌和钙的代谢没有总体负面影响。相反，结果表明，在生物利用率低的饮食中添加NaFeEDTA可能会增加锌的吸收，并提供高生物利用率的铁。
