Jünemann K P, Esen T, Persson-Jünemann C, Seemann O, Alken P
Dept of Urology, Klinikum Mannheim of the University of Heidelberg, Germany.
Ann Urol (Paris). 1994;28(3):132-8.
Various valve mechanisms, customarily employed in continent urinary diversion, were constructed from fresh cadaveric porcine bowel for later urodynamic assessment. A total of six different types of valves were formed from ileum or colon in varying lengths and tested by volume pressure trials. The leak point or maximum pressure were recorded at constant perfusion rates of 30 ml/min of the constructed reservoir. Ileal or colonic nipple valves, as well as the embedded or pulled-through ileum, tapered to 12 F at a length of 3 cm, withstood maximum pressures ranging between 75 and 138 cm H2O before leakage or protrusion of the valve occurred. Plicated or tapered terminal ileum in caecal reservoir revealed water leakage at pressures as low as 25 to 40 cm H2O. A newly-developed valve mechanism consisting of a 12 F, plicated colonic-serosal tunnel with a minimum intra-reservoir length of 5 cm resisted maximum pressures of more than 70 cm H2O. Our cadaveric porcine bowel model proved to be reliable for acute volume/pressure trials and correlated with all clinical urodynamic results and animal trials. It is simple, inexpensive and allows scope for individual ideas before commencing with animal trials.
各种常用于可控性尿流改道的瓣膜机制，均由新鲜的猪尸体肠管构建而成，以供后续的尿动力学评估。总共用不同长度的回肠或结肠形成了六种不同类型的瓣膜，并通过容量压力试验进行测试。在以30 ml/min的恒定灌注速率向构建的储尿囊灌注时，记录渗漏点或最大压力。回肠或结肠乳头瓣，以及埋入或穿过的回肠，在长度为3 cm处逐渐变细至12 F，在瓣膜发生渗漏或突出之前，能承受75至138 cm H₂O的最大压力。盲肠储尿囊中折叠或逐渐变细的末端回肠在低至25至40 cm H₂O的压力下就出现了漏水。一种新开发的瓣膜机制，由一个12 F、折叠的结肠-浆膜隧道组成，储尿囊内的最小长度为5 cm，能承受超过70 cm H₂O的最大压力。我们的猪尸体肠管模型被证明对于急性容量/压力试验是可靠的，并且与所有临床尿动力学结果和动物试验相关。它简单、便宜，并且在开始动物试验之前允许有个人想法的空间。
