双脱氧肌苷在新生猪尾猕猴体内的药代动力学。
Pharmacokinetics of dideoxyinosine in neonatal pigtailed macaques.
作者信息
Pereira C M, Nosbisch C, Unadkat J D
机构信息
Department of Pharmaceutics, University of Washington, Seattle 98195.
出版信息
Antimicrob Agents Chemother. 1994 Apr;38(4):787-9. doi: 10.1128/AAC.38.4.787.
Abstract
To determine whether age affects the pharmacokinetics of dideoxyinosine in neonatal pigtailed macaques (Macaca nemestrina), dideoxyinosine (10 mg/kg of body weight) was administered as a single intravenous bolus to macaques at ages < 1 week, 1 month, and 4 months. Clearance from plasma at < 1 week of age was significantly lower (P < 0.05) and the terminal half-life was significantly higher than the corresponding values obtained at 1 month and 4 months of age. Our data indicate that the pharmacokinetics of dideoxyinosine change significantly with age in M. nemestrina.
摘要
为确定年龄是否会影响新生豚尾猕猴（食蟹猴）体内双脱氧肌苷的药代动力学，分别对年龄小于1周、1个月和4个月的猕猴静脉注射一次大剂量双脱氧肌苷（10毫克/千克体重）。1周龄以下猕猴血浆清除率显著较低（P < 0.05），终末半衰期显著高于1月龄和4月龄猕猴的相应值。我们的数据表明，双脱氧肌苷在食蟹猴体内的药代动力学随年龄显著变化。
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