大鼠体内静脉注射2',3'-双脱氧肌苷与3'-叠氮-3'-脱氧胸苷之间不存在药代动力学相互作用。
Lack of pharmacokinetic interaction between intravenous 2',3'-dideoxyinosine and 3'-azido-3'-deoxythymidine in rats.
作者信息
Wientjes M G, Au J L
机构信息
Department of Surgery, Comprehensive Cancer Center, Columbus, Ohio.
出版信息
Antimicrob Agents Chemother. 1992 Mar;36(3):665-8. doi: 10.1128/AAC.36.3.665.
Abstract
We investigated the pharmacokinetic interaction between 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI), given to rats by intravenous injection. For both compounds, the clearances, terminal half-lives, and fractions of the dose excreted unchanged in urine were not altered by the other drug (P greater than 0.05), indicating no pharmacokinetic interaction between the two drugs.
摘要
我们通过静脉注射给予大鼠3'-叠氮-3'-脱氧胸苷（AZT）和2',3'-双脱氧肌苷（ddI），研究了它们之间的药代动力学相互作用。对于这两种化合物，另一种药物对其清除率、终末半衰期以及尿液中以原形排泄的剂量分数均无影响（P>0.05），表明这两种药物之间不存在药代动力学相互作用。
相似文献
1
Lack of pharmacokinetic interaction between intravenous 2',3'-dideoxyinosine and 3'-azido-3'-deoxythymidine in rats.大鼠体内静脉注射2',3'-双脱氧肌苷与3'-叠氮-3'-脱氧胸苷之间不存在药代动力学相互作用。
Antimicrob Agents Chemother. 1992 Mar;36(3):665-8. doi: 10.1128/AAC.36.3.665.
2
Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes.大鼠、猴和人肝细胞对抗病毒二聚体3'-叠氮-3'-脱氧胸苷-P-2',3'-双脱氧肌苷以及单体齐多夫定和去羟肌苷的代谢比较
Antimicrob Agents Chemother. 1997 Nov;41(11):2502-10. doi: 10.1128/AAC.41.11.2502.
3
Phase I dose-escalation pharmacokinetics of AZT-P-ddI (IVX-E-59) in patients with human immunodeficiency virus.齐多夫定-双去氧肌苷（IVX-E-59）在人类免疫缺陷病毒患者中的I期剂量递增药代动力学
J Clin Pharmacol. 1997 Mar;37(3):201-13. doi: 10.1002/j.1552-4604.1997.tb04782.x.
4
Pharmacokinetics of zidovudine and dideoxyinosine alone and in combination in children with HIV infection.齐多夫定和去羟肌苷单独及联合应用于HIV感染儿童的药代动力学
Br J Clin Pharmacol. 1995 May;39(5):527-30. doi: 10.1111/j.1365-2125.1995.tb04490.x.
5
Pharmacokinetic evaluation of drug interactions with anti-HIV drugs, II: Effect of 2',3'-dideoxyinosine (ddI) on zidovudine kinetics in monkeys.
AIDS Res Hum Retroviruses. 1992 Feb;8(2):277-83. doi: 10.1089/aid.1992.8.277.
6
7
Pharmacokinetics of zidovudine and dideoxyinosine alone and in combination in patients with the acquired immunodeficiency syndrome.齐多夫定与去羟肌苷单独及联合应用于获得性免疫缺陷综合征患者的药代动力学。
Br J Clin Pharmacol. 1994 May;37(5):421-6. doi: 10.1111/j.1365-2125.1994.tb05708.x.
8
Distributed model analysis of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine distribution in brain tissue and cerebrospinal fluid.3'-叠氮-3'-脱氧胸苷和2',3'-双脱氧肌苷在脑组织和脑脊液中分布的分布式模型分析
J Pharmacol Exp Ther. 1997 Sep;282(3):1509-17.
9
Pharmacokinetics of anti-HIV nucleosides in microswine.
J Pharm Pharmacol. 1991 Dec;43(12):823-6. doi: 10.1111/j.2042-7158.1991.tb03187.x.
10
Nonlinear disposition of intravenous 2',3'-dideoxyinosine in rats.
Pharm Res. 1992 Aug;9(8):1070-5. doi: 10.1023/a:1015866714224.
引用本文的文献
1
Renal disposition and drug interaction screening of (-)-2'-deoxy-3'-thiacytidine (3TC) in the isolated perfused rat kidney.
Pharm Res. 1995 Dec;12(12):1958-63. doi: 10.1023/a:1016252225013.
2
Efflux of zidovudine and 2',3'-dideoxyinosine out of the cerebrospinal fluid when administered alone and in combination to Macaca nemestrina.
Pharm Res. 1994 Feb;11(2):312-7. doi: 10.1023/a:1018928013044.
3
Pharmacokinetics of zidovudine and dideoxyinosine alone and in combination in patients with the acquired immunodeficiency syndrome.齐多夫定与去羟肌苷单独及联合应用于获得性免疫缺陷综合征患者的药代动力学。
Br J Clin Pharmacol. 1994 May;37(5):421-6. doi: 10.1111/j.1365-2125.1994.tb05708.x.
4
Effect of zidovudine on transplacental pharmacokinetics of ddI in the pigtailed macaque (Macaca nemestrina).齐多夫定对猪尾猕猴（食蟹猴）中去羟肌苷经胎盘药代动力学的影响。
Antimicrob Agents Chemother. 1995 Feb;39(2):343-5. doi: 10.1128/AAC.39.2.343.
5
Pharmacokinetics of zidovudine and dideoxyinosine alone and in combination in children with HIV infection.齐多夫定和去羟肌苷单独及联合应用于HIV感染儿童的药代动力学
Br J Clin Pharmacol. 1995 May;39(5):527-30. doi: 10.1111/j.1365-2125.1995.tb04490.x.
本文引用的文献
1
Human erythrocytic purine nucleoside phosphorylase: reaction with sugar-modified nucleoside substrates.人红细胞嘌呤核苷磷酸化酶：与糖修饰核苷底物的反应
Biochemistry. 1980 Jan 8;19(1):102-7. doi: 10.1021/bi00542a016.
2
Statistical estimations in pharmacokinetics.药物动力学中的统计学估计
J Pharmacokinet Biopharm. 1974 Apr;2(2):123-48. doi: 10.1007/BF01061504.
3
Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases.3'-叠氮-3'-脱氧胸苷的血浆和脑脊液药代动力学：一种具有治疗艾滋病及相关疾病潜在应用价值的新型嘧啶类似物。
Clin Pharmacol Ther. 1987 Apr;41(4):407-12. doi: 10.1038/clpt.1987.49.
4
Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders. A progress report.
N Engl J Med. 1987 Feb 26;316(9):557-64. doi: 10.1056/NEJM198702263160925.
5
Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity.
Biochem Pharmacol. 1987 Jun 1;36(11):1765-8. doi: 10.1016/0006-2952(87)90235-8.
6
Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex.给艾滋病或艾滋病相关综合征患者使用3'-叠氮-3'-脱氧胸苷，一种HTLV-III/LAV复制抑制剂。
Lancet. 1986 Mar 15;1(8481):575-80. doi: 10.1016/s0140-6736(86)92808-4.
7
Pharmacokinetics and saturable renal tubular secretion of zidovudine in rats.齐多夫定在大鼠体内的药代动力学及肾小管饱和分泌
J Pharm Sci. 1989 Jul;78(7):530-4. doi: 10.1002/jps.2600780704.
8
Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells.人淋巴细胞胞质5'-核苷酸酶对2',3'-二脱氧肌苷的磷酸化作用。
Mol Pharmacol. 1989 Aug;36(2):291-5.
9
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.3'-叠氮-3'-脱氧胸苷的磷酸化及5'-三磷酸酯与人免疫缺陷病毒逆转录酶的选择性相互作用。
Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7. doi: 10.1073/pnas.83.21.8333.
10
Initial clinical experience with dideoxynucleosides as single agents and in combination therapy.
Ann N Y Acad Sci. 1990;616:328-43. doi: 10.1111/j.1749-6632.1990.tb17853.x.
Zotero 插件