Echelman D A, Nasisse M P, Shields M B, McGahan M C, Fleisher L N
Department of Ophthalmology, Duke University Medical Center, Durham, NC.
Arch Ophthalmol. 1994 Jul;112(7):977-81. doi: 10.1001/archopht.1994.01090190125032.
To evaluate the influence of duration of exposure on the inflammatory response to transscleral neodymium:YAG cyclophotocoagulation.
Transscleral cyclophotocoagulation was performed with a contact, Nd:YAG, continuous-wave laser on one eye of 48 Dutch belted rabbits, 10 W and 0.2 second used in half and 1 W and 2 seconds in the other half. One third of each group was evaluated on the operative day and the other thirds on postoperative days 3 and 10. Tissue reaction was inspected grossly and by light microscopy, and inflammatory responses were measured by aqueous leukocyte and erythrocyte counts, aqueous and vitreous protein levels, aqueous prostaglandin levels, and iris and ciliary body myeloperoxidase activity.
The shorter-duration protocol was associated with more ciliary epithelial disruption and significantly greater inflammatory responses by one or more of the measures at all times.
When energy is constant, a shorter duration of exposure with transscleral Nd:YAG cyclophotocoagulation in rabbits is associated with greater tissue disruption and inflammation.
评估暴露时间对经巩膜钕：钇铝石榴石激光睫状体光凝术炎症反应的影响。
对48只荷兰带兔的一只眼睛进行经巩膜睫状体光凝术，使用接触式钕：钇铝石榴石连续波激光，一半兔子使用10W、0.2秒，另一半使用1W、2秒。每组的三分之一在手术当天进行评估，另外三分之一在术后第3天和第10天进行评估。通过肉眼和光学显微镜检查组织反应，并通过房水白细胞和红细胞计数、房水和玻璃体蛋白水平、房水前列腺素水平以及虹膜和睫状体髓过氧化物酶活性来测量炎症反应。
短时间方案与更多的睫状体上皮破坏相关，并且在所有时间点通过一种或多种测量方法，炎症反应明显更大。
当能量恒定时，兔子经巩膜钕：钇铝石榴石激光睫状体光凝术的暴露时间越短，组织破坏和炎症越大。
