Bielajew C, Trzcińska M
School of Psychology, University of Ottawa, Ont., Canada.
Behav Brain Res. 1994 Mar 31;61(1):29-35. doi: 10.1016/0166-4328(94)90005-1.
Double pulse tests were used to infer the refractory periods of the substrate underlying stimulation-induced feeding in the sulcal prefrontal cortex of the rat. Eleven sites were examined, of which five supported the behaviour at currents of 250 to 400 microA; pulse duration was 100 microseconds. The average profile indicates a recovery function that begins at 0.5 ms and ends at 3.0 ms, with no apparent contribution from local potential summations. The mean effectiveness value corresponding to the asymptotic portion of the curves was 91%. These results suggest that there is substantial overlap in the excitability of neurons underlying stimulation-induced feeding in the sulcal prefrontal cortex and that reported for the medial forebrain bundle, but unlike the latter structure, there is no evidence of self-stimulation from the same sulcal prefrontal cortex placements. Response rates were collected for a maximum of 21 days from each of the cortical sites at which feeding was recorded and at the same currents used to evaluate the refractory periods underlying stimulation-induced feeding. The rates averaged between 0 and 3 responses per minute whether the current was available or not. These data represent the first demonstration of a site that supports stimulation-induced feeding in the absence of brain stimulation reward, at least at these specific placements and stimulation parameters.
双脉冲测试被用于推断大鼠脑沟前额叶皮质中刺激诱导进食的基础底物的不应期。共检查了11个位点，其中5个位点在250至400微安的电流下支持该行为；脉冲持续时间为100微秒。平均曲线表明恢复功能从0.5毫秒开始，在3.0毫秒结束，局部电位总和没有明显贡献。对应于曲线渐近部分的平均有效性值为91%。这些结果表明，脑沟前额叶皮质中刺激诱导进食的基础神经元兴奋性与内侧前脑束报道的情况有很大重叠，但与后一种结构不同，没有证据表明从相同的脑沟前额叶皮质位点进行自我刺激。在记录到进食的每个皮质位点，以用于评估刺激诱导进食的不应期的相同电流，最多收集21天的反应率。无论电流是否可用，反应率平均每分钟0至3次。这些数据首次证明了在没有脑刺激奖励的情况下，至少在这些特定的位点和刺激参数下，存在支持刺激诱导进食的位点。
