Legius E, Descheemaeker M J, Spaepen A, Casaer P, Fryns J P
Center for Human Genetics, University Hospital Gasthuisberg, Leuven, Belgium.
Genet Couns. 1994;5(1):51-60.
Developmental testing (7 children, aged between 17 months and 4 years) and intelligence profile analysis (38 children, aged between 4 and 16 years) were performed in a group of 45 children with NF1 followed at the Leuven NF clinic. Mental retardation (total IQ < 70) was noted in 2 of the 38 children between 4 and 16 years (5.2%). The mean total IQ of this group was 89.9 with a significantly higher verbal IQ than performed IQ. Factor analysis according to Kaufman showed a significantly weaker score on perceptual organization as compared with verbal comprehension. Concentration difficulty as measured by the Freedom from Distractibility Factor of Kaufman was not an important problem in the total group of children, but was more significant in the group of children with a total IQ above 85. Subtest analysis also showed significantly better scores on some verbal comprehensive tests as compared with some perceptual organization tests. Learning disabilities were frequent in the children analyzed in this report and non-verbal learning disabilities were the predominant type (40% of children). However other types and combinations of different types of learning disabilities were also found.
在鲁汶神经纤维瘤病诊所对45名患有神经纤维瘤病1型（NF1）的儿童进行了发育测试（7名儿童，年龄在17个月至4岁之间）和智力剖析分析（38名儿童，年龄在4岁至16岁之间）。在38名4至16岁的儿童中，有2名（5.2%）存在智力发育迟缓（总智商<70）。该组儿童的平均总智商为89.9，言语智商显著高于操作智商。根据考夫曼进行的因素分析显示，与言语理解相比，知觉组织得分明显较低。考夫曼注意力分散因子测量的注意力集中困难在儿童总体中不是一个重要问题，但在总智商高于85的儿童组中更为显著。分测验分析还显示，与一些知觉组织测验相比，某些言语综合测验的得分明显更高。在本报告分析的儿童中，学习障碍很常见，非言语学习障碍是主要类型（占儿童的40%）。然而，也发现了其他类型以及不同类型学习障碍的组合。
