Anderson A, Morgan O, Morgan T
Hypertension Clinic, Repatriation Hospital, Heidelberg, Australia.
Am J Hypertens. 1994 Apr;7(4 Pt 1):371-3. doi: 10.1093/ajh/7.4.371.
Ten patients who had their blood pressure controlled with enalapril (10 mg, n = 4; 20 mg, n = 6) and 10 control subjects on perindopril (4 mg, n = 6; 8 mg, n = 4) entered a double-blind crossover study. They received placebo or the active drug 1 week apart and had their blood pressure measured at 0, 2, 3, 4, and 24 h. Then they crossed over to the other angiotensin-converting enzyme inhibitors (4 mg perindopril congruent to 10 mg enalapril) and the double-blind study was repeated. Blood pressure control 2 to 4 h after drug administration was similar with both drugs (perindopril = 150 +/- 2/80 +/- 1; enalapril = 150 +/- 2/81 +/- 1). Twenty-four h after administration of perindopril blood pressure was lower than on enalapril (perindopril = 154 +/- 3/85 +/- 2; enalapril = 159 +/- 3/89 +/- 2). Enalapril, 2 to 4 h after administration, caused a greater decrease than placebo, whereas the change with perindopril did not differ from placebo. Twenty-four hours after receiving the active drug the blood pressure of subjects on perindopril did not differ from the peak effect when corrected for placebo and circadian variation, whereas the blood pressure on enalapril was higher. This study indicates that perindopril in the doses used has a longer duration of action than enalapril and is more suited to once daily use.
10名使用依那普利（10毫克，n = 4；20毫克，n = 6）控制血压的患者和10名服用培哚普利（4毫克，n = 6；8毫克，n = 4）的对照受试者进入了一项双盲交叉研究。他们每隔1周接受安慰剂或活性药物治疗，并在0、2、3、4和24小时测量血压。然后他们交叉使用另一种血管紧张素转换酶抑制剂（4毫克培哚普利相当于10毫克依那普利），并重复双盲研究。两种药物给药后2至4小时的血压控制情况相似（培哚普利 = 150±2/80±1；依那普利 = 150±2/81±1）。服用培哚普利24小时后的血压低于服用依那普利后的血压（培哚普利 = 154±3/85±2；依那普利 = 159±3/89±2）。依那普利给药后2至4小时引起的血压下降幅度大于安慰剂，而培哚普利引起的变化与安慰剂无差异。接受活性药物24小时后，校正安慰剂和昼夜变化后，服用培哚普利的受试者的血压与峰值效应无差异，而服用依那普利的受试者的血压更高。这项研究表明，所用剂量的培哚普利比依那普利作用持续时间更长，更适合每日一次使用。
