Acosta A A, Buttram V C, Malinak L R, Besch P K, Franklin R R
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
Fertil Steril. 1975 Dec;26(12):1173-7. doi: 10.1016/s0015-0282(16)41530-x.
Each of 14 anovulatory patients received a single injection of 150 micrograms of synthetic luteinizing hormone-releasing hormone (LH-RH) in one induced menstrual cycle. In two subsequent cycles, patients were pretreated with clomiphene before LH-RH injection. Four patients received LH-RH after pretreatment with human menopausal gonadotropin (HMG) in another cycle. In each cycle, gonadotropin release and ovulation were recorded. All patients had previously failed to ovulate when treated with large doses of clomiphene. No patient ovulated following injection of LH-RH alone, although five patients exhibited a good pituitary response. Nine patients ovulated when they received LH-RH after pretreatment with clomiphene, and one patient ovulated when pretreated with HMG. The diagnostic value of a single injection of LH-RH is not clear. In the present study, gonadotropin response to LH-RH was not an entirely accurate predictor of a patient's ovulatory response in any of the four cycles. On the other hand, when clomiphene-LH-RH was administered, a good response was associated with ovulation in that cycle. The exact role of LH-RH in inducing ovulation is unclear, but the results of using LH-RH in conjunction with clomiphene are encouraging enough to warrant continued use and further study.
14名无排卵患者在1个诱导月经周期中均接受了单次注射150微克合成促黄体生成素释放激素（LH-RH）的治疗。在随后的2个周期中，患者在注射LH-RH前先用克罗米芬进行预处理。在另一个周期中，4名患者在用人绝经期促性腺激素（HMG）预处理后接受LH-RH治疗。在每个周期中，均记录促性腺激素释放情况及排卵情况。所有患者此前用大剂量克罗米芬治疗时均未排卵。单独注射LH-RH后无患者排卵，尽管有5名患者表现出良好的垂体反应。9名患者在克罗米芬预处理后接受LH-RH治疗时排卵，1名患者在HMG预处理后排卵。单次注射LH-RH的诊断价值尚不清楚。在本研究中，在4个周期中的任何一个周期里，促性腺激素对LH-RH的反应都不是患者排卵反应的完全准确预测指标。另一方面，当给予克罗米芬-LH-RH时，良好的反应与该周期排卵相关。LH-RH在诱导排卵中的确切作用尚不清楚，但LH-RH与克罗米芬联合使用的结果足以令人鼓舞，值得继续使用并进一步研究。
