Wang Z, Li F
Institute of Basic Medical Sciences, CAMS, Beijing.
Chin Med Sci J. 1993 Dec;8(4):215-7.
Ilexonin A (Ile A) is an effective compound isolated from Ilex pubescens Hook et Arn which has been found to inhibit platelet aggregation and Ca2+ influx in platelets. The present experiments were designed to observe the effects of Ile A on platelet metabolism. Verapamil (Ver) was used as control. The results indicated that thrombin significantly reduced the level of platelet cAMP, while Ile A and Ver obviously antagonized this effect. The inhibition of the activity of platelet phosphodiesterase by Ile A was much stronger than that by Ver. The results suggest that Ile A may be beneficial in the treatment of cardiovascular disease.
毛冬青甲素（Ile A）是从毛冬青中分离得到的一种有效化合物，已发现它能抑制血小板聚集和血小板中的钙离子内流。本实验旨在观察毛冬青甲素对血小板代谢的影响。以维拉帕米（Ver）作为对照。结果表明，凝血酶显著降低了血小板环磷酸腺苷（cAMP）水平，而毛冬青甲素和维拉帕米明显拮抗了这一作用。毛冬青甲素对血小板磷酸二酯酶活性的抑制作用比维拉帕米强得多。结果提示，毛冬青甲素可能对心血管疾病的治疗有益。
