Ye T, Luo A, Ren H, Xu J, Gao M
Department of Anesthesiology, PUMC Hospital, CAMS, Beijing.
Chin Med Sci J. 1993 Dec;8(4):240-2.
Urapidil (Ebrantil), a new antihypertensive agent with central and peripheral sites of action, has proven effective in the management of both chronic and acute hypertension. This study investigates its effects on cardiovascular responses during intubation and extubation under general anesthesia. Thirty normotensive patients (ASA I-II) were randomized into control (I, without urapidil, n = 10); lower dose (II, 0.4 mg/kg, n = 10); and higher dose (III, 0.6 mg/kg, n = 10) groups. A significant fall of blood pressure was observed in all patients within 1 min after urapidil administration (P < 0.05), and the magnitude of the decrease was related to blood pressure before treatment. However, no transient drop of blood pressure to hypotensive values was observed. The results suggest that urapidil could be used under general anesthesia in patients to control fluctuating blood pressure during intubation and extubation. The increased heart rate (P < 0.05) seen for several minutes after urapidil administration may have been due to the patients' hypovolemic state.
乌拉地尔（压宁定）是一种具有中枢和外周作用部位的新型抗高血压药物，已被证明在治疗慢性和急性高血压方面有效。本研究调查了其在全身麻醉下插管和拔管期间对心血管反应的影响。30例血压正常的患者（ASA I-II级）被随机分为对照组（I组，未使用乌拉地尔，n = 10）；低剂量组（II组，0.4 mg/kg，n = 10）；和高剂量组（III组，0.6 mg/kg，n = 10）。在给予乌拉地尔1分钟内，所有患者的血压均显著下降（P < 0.05），且下降幅度与治疗前血压相关。然而，未观察到血压短暂降至低血压值。结果表明，乌拉地尔可用于全身麻醉下的患者，以控制插管和拔管期间波动的血压。乌拉地尔给药后几分钟内出现的心率增加（P < 0.05）可能是由于患者的低血容量状态。
