Georgiou D, Wolfkiel C, Brundage B H
Division of Cardiology, Harbor-UCLA Medical Center, Torrance 90509.
Am J Card Imaging. 1994 Apr;8(2):151-8.
Quantitation of myocardial blood flow has been sought by the clinician using a variety of imaging modalities and blood indicator dilution techniques. Ultrafast computed tomography has real potential for clinically useful estimations of regional myocardial blood flow. At the present time, there are limitations with this technique and early washout of indicator (iodine) appears to be the most likely explanation for the inaccuracies observed. Several methods have been tried to correct for early washout without success. Preliminary data based on a new algorithm look promising. Currently available techniques for detecting and quantifying myocardial ischemia have significant limitations. A noninvasive method able to determine wide ranges of flow with accuracy will be essential to understand the pathophysiology of ischemia and for directing better methods of managing ischemic heart disease.
临床医生一直通过各种成像方式和血液指示剂稀释技术来寻求心肌血流量的定量方法。超快速计算机断层扫描在临床上对区域心肌血流量进行有用估计方面具有真正的潜力。目前，该技术存在局限性，指示剂（碘）的早期洗脱似乎是观察到的不准确现象的最可能解释。已经尝试了几种方法来校正早期洗脱，但均未成功。基于一种新算法的初步数据看起来很有前景。目前可用的检测和量化心肌缺血的技术存在重大局限性。一种能够准确测定大范围血流量的非侵入性方法对于理解缺血的病理生理学以及指导更好的缺血性心脏病管理方法至关重要。
