Efstratiadis A
Department of Genetics and Development, Columbia University, New York, New York 10032.
Curr Opin Genet Dev. 1994 Apr;4(2):265-80. doi: 10.1016/s0959-437x(05)80054-1.
The molecular mechanisms introducing epigenetic modifications that lead to differential silencing of some autosomal alleles depending on their parental legacy are still largely unknown, but recent results from studies of endogenously imprinted genes and particular transgenes make DNA methylation a strong candidate. At the same time, these results have raised new questions about the details of the imprinting process.
导致某些常染色体等位基因根据其亲本遗传而产生差异沉默的表观遗传修饰的分子机制在很大程度上仍然未知，但来自内源性印记基因和特定转基因研究的最新结果使DNA甲基化成为一个有力的候选因素。与此同时，这些结果对印记过程的细节提出了新的问题。
