Steers W D
Department of Urology, University of Virginia, Health Sciences Center, Charlottesville 22908.
Neurourol Urodyn. 1994;13(2):97-118. doi: 10.1002/nau.1930130204.
Despite the development of molecular and cellular methods for examining physiological processes, the use of the whole animal model remains essential to advance knowledge regarding the integration and coordination of events associated with urinary tract function. The rat offers an inexpensive and versatile species to investigate bladder and urethral responses to drugs or pathology. Models for many disorders have been developed in rodents including diabetes, multiple sclerosis, spinal cord injury, Parkinson's disease, bladder outlet obstruction, pain, and aging. This review examines methodologies to evaluate lower urinary tract function and manipulations used to create pathological models in rodents.
尽管用于研究生理过程的分子和细胞方法不断发展，但使用全动物模型对于推进有关与尿路功能相关事件的整合与协调的知识仍然至关重要。大鼠是一种廉价且通用的物种，可用于研究膀胱和尿道对药物或病理状况的反应。在啮齿动物中已经开发出许多疾病的模型，包括糖尿病、多发性硬化症、脊髓损伤、帕金森病、膀胱出口梗阻、疼痛和衰老。本综述探讨了评估啮齿动物下尿路功能的方法以及用于创建病理模型的操作。
