Ravn V, Mandel U, Svenstrup B, Dabelsteen E
Department of Pathology, Righospitalet, Blegdamsvej, Denmark.
Virchows Arch. 1994;424(5):495-502. doi: 10.1007/BF00191435.
Type-1 chain histo-blood group antigens such as the Lewis (Le)a, monosialosyl-Le(a), Le(b) and H antigens show an increased expression in endometrial carcinomas. However, the possibility that these antigens are expressed under genetic or hormonal influence in endometrial carcinomas has not been considered. In the present study, the expression of type-1 chain carbohydrate antigens in normal and malignant endometrium was evaluated by immunohistochemistry and related to both genetic and hormonal factors. The glands of normal, non-secretory endometria expressed, in contrast with surface epithelial cells, Le(a), Le(b), disialosyl-Le(a), and H determinants infrequently. Adenomatous hyperplasias and endometrial carcinomas showed an increased expression of type-1 chain carbohydrates that was qualitatively influenced by the erythrocyte Lewis phenotype and the secretor status. Whereas Le(a+b-) non-secretors mainly accumulated Le(a) antigen, and only limited amounts of Le(b) antigen, Le(a-b+) secretors expressed H, Le(b) and Le(a) antigens. The expression of type-1 chain antigens showed no association with the serum-oestrogen level or to the hormone-receptor status. Thus the Lewis secretor status has a qualitative influence on the increased expression of type-1 chain antigens, which, however, seem to be unrelated to hormonal factors. Our findings suggest an increased activity of the Se-gene-defined or a closely related fucosyl-transferase in neoplastic endometrial epithelial cells.
1型链组织血型抗原，如Lewis（Le）a、单唾液酸基-Le（a）、Le（b）和H抗原，在子宫内膜癌中表达增加。然而，尚未考虑这些抗原在子宫内膜癌中受遗传或激素影响而表达的可能性。在本研究中，通过免疫组织化学评估了正常和恶性子宫内膜中1型链碳水化合物抗原的表达，并将其与遗传和激素因素相关联。与表面上皮细胞相比，正常的非分泌期子宫内膜腺体很少表达Le（a）、Le（b）、二唾液酸基-Le（a）和H决定簇。腺瘤样增生和子宫内膜癌显示1型链碳水化合物表达增加，其在质量上受红细胞Lewis表型和分泌状态的影响。Le（a+b-）非分泌者主要积累Le（a）抗原，仅有限量的Le（b）抗原，而Le（a-b+）分泌者表达H、Le（b）和Le（a）抗原。1型链抗原的表达与血清雌激素水平或激素受体状态无关。因此，Lewis分泌状态对1型链抗原表达的增加有质量上的影响，然而，这似乎与激素因素无关。我们的研究结果表明，在肿瘤性子宫内膜上皮细胞中，Se基因定义的或与之密切相关的岩藻糖基转移酶的活性增加。
