B2 激肽受体拮抗剂 Hoe 140 对抗原诱导的鼻阻塞的减轻作用。
Reduction by Hoe 140, the B2 kinin receptor antagonist, of antigen-induced nasal blockage.
作者信息
Austin C E, Foreman J C, Scadding G K
机构信息
Department of Pharmacology, University College London.
出版信息
Br J Pharmacol. 1994 Apr;111(4):969-71. doi: 10.1111/j.1476-5381.1994.tb14835.x.
Abstract
In subjects with allergic rhinitis to house-dust mite (HDM), antigen challenge produced a significant increase in nasal blockage but had no effect on nasal vascular permeability. The B2 kinin receptor antagonist, [D-Arg0,Hyp3,Thi5,D-Tic7,Oic8]-bradykinin (Hoe 140), 200 micrograms administered by intranasal aerosol 2 min prior to challenge with HDM, 500 u significantly reduced nasal blockage induced by the antigen challenge. The data are compatible with a role for B2 kinin receptors in the nasal response to challenge with antigen which is responsible for nasal blockage.
摘要
在对屋尘螨（HDM）过敏的鼻炎患者中，抗原激发可导致鼻阻塞显著增加，但对鼻血管通透性无影响。在用500单位HDM激发前2分钟经鼻气雾剂给予200微克B2激肽受体拮抗剂[D-Arg0，Hyp3，Thi5，D-Tic7，Oic8]-缓激肽（Hoe 140），可显著减轻抗原激发引起的鼻阻塞。这些数据表明B2激肽受体在对抗原激发的鼻反应中起作用，而这种反应会导致鼻阻塞。
相似文献
1
Reduction by Hoe 140, the B2 kinin receptor antagonist, of antigen-induced nasal blockage.B2 激肽受体拮抗剂 Hoe 140 对抗原诱导的鼻阻塞的减轻作用。
Br J Pharmacol. 1994 Apr;111(4):969-71. doi: 10.1111/j.1476-5381.1994.tb14835.x.
2
Characterization of the bradykinin receptor in the human nasal airway using the binding of [125I]-Hoe 140.利用[125I]-Hoe 140的结合对人鼻气道中的缓激肽受体进行表征。
Br J Pharmacol. 1996 Nov;119(5):1054-62. doi: 10.1111/j.1476-5381.1996.tb15777.x.
3
Role of kinins in seasonal allergic rhinitis: icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen.激肽在季节性变应性鼻炎中的作用：缓激肽B2受体拮抗剂艾替班特可消除抗原诱导的高反应性和鼻嗜酸性粒细胞增多。
J Allergy Clin Immunol. 2001 Jan;107(1):105-13. doi: 10.1067/mai.2001.111145.
4
A study of the action of bradykinin and bradykinin analogues in the human nasal airway.缓激肽及缓激肽类似物在人体鼻气道中的作用研究。
J Physiol. 1994 Jul 15;478 ( Pt 2)(Pt 2):351-6. doi: 10.1113/jphysiol.1994.sp020255.
5
Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse.B1和B2激肽受体参与小鼠福尔马林诱导的伤害性反应的证据。
Br J Pharmacol. 1993 Sep;110(1):193-8. doi: 10.1111/j.1476-5381.1993.tb13791.x.
6
Bradykinin B2 receptors and coupling mechanisms in the smooth muscle of the guinea-pig taenia caeci.豚鼠盲肠带平滑肌中的缓激肽B2受体及其偶联机制
Br J Pharmacol. 1994 Oct;113(2):607-13. doi: 10.1111/j.1476-5381.1994.tb17033.x.
7
Characterization of bradykinin receptors mediating catecholamine release in PC12 cells.介导PC12细胞中儿茶酚胺释放的缓激肽受体的特性研究
Naunyn Schmiedebergs Arch Pharmacol. 1995 Mar;351(3):274-81. doi: 10.1007/BF00233247.
8
The longitudinal muscle of rat ileum as a sensitive monoreceptor assay for bradykinin B1 receptors.大鼠回肠纵行肌作为缓激肽B1受体的敏感单受体检测方法。
Br J Pharmacol. 1996 Apr;117(8):1619-24. doi: 10.1111/j.1476-5381.1996.tb15331.x.
9
The expression of functionally-coupled B2-bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists.人角膜上皮细胞中功能偶联的B2-缓激肽受体的表达及其激动剂和拮抗剂的药理学特性
Br J Pharmacol. 1997 Jun;121(4):649-56. doi: 10.1038/sj.bjp.0701168.
10
Cardiovascular effects of intrathecally administered bradykinin in the rat: characterization of receptors with antagonists.鞘内注射缓激肽对大鼠心血管系统的影响：用拮抗剂对受体进行特性分析
Br J Pharmacol. 1993 Dec;110(4):1369-74. doi: 10.1111/j.1476-5381.1993.tb13971.x.
引用本文的文献
1
A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases.关于缓激肽在 COVID-19 和炎症性疾病中的最新认识的全面综述。
Mol Biol Rep. 2022 Oct;49(10):9915-9927. doi: 10.1007/s11033-022-07539-2. Epub 2022 May 21.
2
Specific immunotherapy with mugwort pollen allergoid reduce bradykinin release into the nasal fluid.用艾蒿花粉类变应原进行特异性免疫疗法可减少缓激肽释放到鼻分泌物中。
Postepy Dermatol Alergol. 2016 Aug;33(4):269-75. doi: 10.5114/ada.2016.61602. Epub 2016 Aug 16.
3
Immunohistochemical localization of the bradykinin B1 and B2 receptors in human nasal mucosa.缓激肽B1和B2受体在人鼻黏膜中的免疫组织化学定位
Mediators Inflamm. 2009;2009:102406. doi: 10.1155/2009/102406. Epub 2009 Apr 23.
4
Suppressive effect of distinct bradykinin B2 receptor antagonist on allergen-evoked exudation and leukocyte infiltration in sensitized rats.不同缓激肽B2受体拮抗剂对致敏大鼠变应原诱发的渗出和白细胞浸润的抑制作用。
Br J Pharmacol. 1999 May;127(2):315-20. doi: 10.1038/sj.bjp.0702536.
5
Kinin receptors.激肽受体
Clin Rev Allergy Immunol. 1998 Winter;16(4):385-401. doi: 10.1007/BF02737658.
6
The kinin system in rhinitis and asthma.鼻炎和哮喘中的激肽系统。
Clin Rev Allergy Immunol. 1998 Winter;16(4):351-64. doi: 10.1007/BF02737656.
7
Characterization of the bradykinin receptor in the human nasal airway using the binding of [125I]-Hoe 140.利用[125I]-Hoe 140的结合对人鼻气道中的缓激肽受体进行表征。
Br J Pharmacol. 1996 Nov;119(5):1054-62. doi: 10.1111/j.1476-5381.1996.tb15777.x.
8
Attenuation of human nasal airway responses to bradykinin and histamine by inhibitors of nitric oxide synthase.一氧化氮合酶抑制剂对人鼻气道对缓激肽和组胺反应的抑制作用
Br J Pharmacol. 1996 Jul;118(5):1177-82. doi: 10.1111/j.1476-5381.1996.tb15521.x.
本文引用的文献
1
Acoustic rhinometry compared with posterior rhinomanometry in the measurement of histamine- and bradykinin-induced changes in nasal airway patency.在测量组胺和缓激肽引起的鼻气道通畅性变化方面，声反射鼻测量法与后鼻测压法的比较。
Br J Clin Pharmacol. 1994 Jan;37(1):33-7. doi: 10.1111/j.1365-2125.1994.tb04235.x.
2
Mediator release after nasal airway challenge with allergen.变应原进行鼻气道激发后介质的释放。
Am Rev Respir Dis. 1983 Oct;128(4):597-602. doi: 10.1164/arrd.1983.128.4.597.
3
Measurement of feelings using visual analogue scales.使用视觉模拟量表测量情感。
Proc R Soc Med. 1969 Oct;62(10):989-93. doi: 10.1177/003591576906201005.
4
The inhibition of glandular kallikrein by peptide analog antagonists of bradykinin.
Peptides. 1988 Jan-Feb;9(1):203-6. doi: 10.1016/0196-9781(88)90028-9.
5
Nasal provocation with bradykinin induces symptoms of rhinitis and a sore throat.
Am Rev Respir Dis. 1988 Mar;137(3):613-6. doi: 10.1164/ajrccm/137.3.613.
6
Albumin, bradykinins, and eosinophil cationic protein on the nasal mucosal surface in patients with hay fever during natural allergen exposure.
J Allergy Clin Immunol. 1990 May;85(5):828-33. doi: 10.1016/0091-6749(90)90064-b.
7
Comparative nasal effects of bradykinin, kallidin and [Des-Arg9]-bradykinin in atopic rhinitic and normal volunteers.缓激肽、胰激肽和[去-精氨酸9]-缓激肽对特应性鼻炎患者和正常志愿者鼻腔的比较作用
J Physiol. 1991 Jun;437:577-87. doi: 10.1113/jphysiol.1991.sp018612.
8
Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies.Hoe 140一种新型强效长效缓激肽拮抗剂：体外研究
Br J Pharmacol. 1991 Mar;102(3):769-73. doi: 10.1111/j.1476-5381.1991.tb12248.x.
Zotero 插件