外周型苯二氮䓬受体在运动神经和骨骼肌上的药理学意义。
Pharmacological relevance of peripheral type benzodiazepine receptors on motor nerve and skeletal muscle.
作者信息
Chiou L C, Chang C C
机构信息
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei.
出版信息
Br J Pharmacol. 1994 May;112(1):257-61. doi: 10.1111/j.1476-5381.1994.tb13060.x.
Abstract
- Effects of agonists and antagonists of peripheral and central benzodiazepine receptors (pBZR and cBZR) on neuromuscular transmission were studied in mouse isolated phrenic nerve-diaphragm preparations. 2. Ro5-4864, a pBZR agonist, had no effect on the neuromuscular transmission but increased muscle contractility and antagonized the tetanic fade induced by neostigmine. 3. Ro5-4864 inhibited the regenerative tonic endplate depolarization caused by repetitive stimulation in the presence of neostigmine without affecting the amplitude and decay time of miniature and evoked single endplate potentials. 4. All the effects of Ro5-4864 were shared by PK11195, a pBZR antagonist, but not by clonazepam and flumazenil, a cBZR agonist and antagonist, respectively. 5. It is suggested that peripheral type benzodiazepine receptors modulate presynaptic function and muscle contraction.
摘要
- 在小鼠离体膈神经-膈肌标本中研究了外周和中枢苯二氮䓬受体（pBZR和cBZR）激动剂和拮抗剂对神经肌肉传递的影响。2. pBZR激动剂Ro5-4864对神经肌肉传递无影响，但增加了肌肉收缩力，并拮抗了新斯的明诱导的强直衰减。3. Ro5-4864在新斯的明存在的情况下抑制了重复刺激引起的再生性强直终板去极化，而不影响微小和诱发的单个终板电位的幅度和衰减时间。4. Ro5-4864的所有作用均被pBZR拮抗剂PK11195所共有，但cBZR激动剂氯硝西泮和拮抗剂氟马西尼则没有这些作用。5. 提示外周型苯二氮䓬受体调节突触前功能和肌肉收缩。
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本文引用的文献
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