Frenkel' M A, Sokirka T E, Lebedeva N B, Tupitsyn N N, Baryshnikov A Iu, Solov'eva E A
Klin Lab Diagn. 1993 Nov-Dec(6):32-7.
Morphocytochemical and immunologic features of the bone marrow and peripheral blood lymphoid elements were studied in 40 patients with B-prolymphocytic lymphosarcoma in the stage of leukemic degeneration. Four types of pathologic lymphoid cells were distinguished: large prolymphocytes expressing pan-B CD19 and HLA-Dr antigens, medium-sized prolymphocytes with round nuclei, characterized by activation CD38 and CD45Ra antigens, prolymphocytes with split nuclei containing light and heavy immunoglobulin chains, and leukemic lymphocytes containing, besides pan-B antigens and immunoglobulins, antigens of the early hemopoietic (CD34) and early B-(CD10) precursors. The content of the RAS-positive substance in the prolymphocytes was inversely proportional to the parameters of activation antigens expression. Acid phosphatase activity correlated with the expression of CD22 and CD45Ra antigens.
对40例处于白血病退变期的B-原淋巴细胞性淋巴肉瘤患者的骨髓和外周血淋巴细胞成分进行了形态细胞化学和免疫学特征研究。区分出四种类型的病理性淋巴细胞：表达泛B CD19和HLA-Dr抗原的大原淋巴细胞、具有圆形核的中等大小原淋巴细胞（其特征为激活的CD38和CD45Ra抗原）、具有分裂核且含有轻链和重链免疫球蛋白的原淋巴细胞，以及除泛B抗原和免疫球蛋白外还含有早期造血（CD34）和早期B-（CD10）前体抗原的白血病淋巴细胞。原淋巴细胞中RAS阳性物质的含量与激活抗原表达参数呈负相关。酸性磷酸酶活性与CD22和CD45Ra抗原的表达相关。
