在开始使用氯氮平期间使用水合氯醛和异戊巴比妥钠。

The use of chloral hydrate and sodium amytal during clozapine initiation.

作者信息

Dickson R A, Williams R, Dalby J T

机构信息

Department of Psychiatry, University of Calgary, Alberta.

出版信息

Can J Psychiatry. 1994 Apr;39(3):132-4. doi: 10.1177/070674379403900302.

DOI:10.1177/070674379403900302

PMID:8033016

Abstract

Sedative hypnotics are frequently a necessary adjunctive to neuroleptic treatment. The recently released antipsychotic agent clozapine poses a challenge in this regard since the manufacturer advises caution when using clozapine with patients receiving benzodiazepines. The effectiveness of alternate agents sodium amytal and chloral hydrate when initiating clozapine was evaluated in a group of 15 patients suffering from schizophrenia. These medications were observed to be both safe and effective.

摘要

镇静催眠药常常是抗精神病药物治疗的必要辅助药物。最近上市的抗精神病药物氯氮平在这方面带来了挑战，因为生产商建议在氯氮平与接受苯二氮䓬类药物治疗的患者合用时要谨慎。在一组15例精神分裂症患者中评估了在开始使用氯氮平时替代药物戊巴比妥钠和水合氯醛的有效性。观察发现这些药物既安全又有效。