Singh H, Levinson D F, Simpson G M, Lo E S, Friedman E
Department of Psychiatry, Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129.
J Clin Psychopharmacol. 1990 Dec;10(6):389-96. doi: 10.1097/00004714-199010060-00002.
Eighty-six patients with acute psychotic exacerbations were treated with fixed dosage regimens of oral fluphenazine up to 10-30 mg/day in randomized, double-blind studies. Dystonic reactions occurred in 33.8% of the subjects at risk. Of these, 58% occurred by the third day, 88% by the fourth day, and 100% by the ninth day of treatment; most occurred later in the interdose interval. Significant predictors of dystonic reactions were higher fluphenazine mg/kg dosage and younger age. There was a trend toward a lower risk of dystonia in patients who received amobarbital sodium for agitation. Results are discussed in relation to possible mechanisms of neuroleptic-induced dystonia.
在随机双盲研究中，86例急性精神病性发作患者接受了每日高达10 - 30毫克的固定剂量口服氟奋乃静治疗方案。有33.8%的受试者出现了肌张力障碍反应。其中，58%在治疗第三天出现，88%在第四天出现，100%在第九天出现；大多数发生在给药间隔后期。肌张力障碍反应的显著预测因素是较高的氟奋乃静毫克/千克剂量和较年轻的年龄。接受异戊巴比妥钠治疗躁动的患者发生肌张力障碍的风险有降低趋势。本文结合抗精神病药物所致肌张力障碍的可能机制对结果进行了讨论。
