Xue P
National Institute for the Control of Pharmaceutical and Biological Products, Beijing.
Zhonghua Jie He He Hu Xi Za Zhi. 1993 Dec;16(6):360-2, 376.
The authors compared the influence of BCG produced strains D1 and D2 vaccination on lymphocyte transformation of spleen lymphocytes from guinea pigs. The guinea pigs were divided into D1 strain vaccinated group, D2 strain vaccinated group and nonvaccinated group. The response of lymphocyte transformation of spleen lymphocytes from the three groups to the stimulation of PHA, ConA and PPD were compared at 3, 4, and 5 weeks following vaccination. It was shown that the lymphocyte proliferation of D2 strain vaccinated guinea pigs to the stimulation of PHA, ConA and PPD was higher than that of D1 strain vaccinated. The most sensitivity of immunized lymphocytes to PHA and ConA was at 4 weeks following vaccination. Lymphocytes proliferation to PPD at 5 weeks following vaccination was higher than that at 4 weeks. This study showed that the ability of D2 strain to elicit the CMI was more than that of D1 strain.
作者比较了卡介苗生产菌株D1和D2疫苗接种对豚鼠脾脏淋巴细胞转化的影响。将豚鼠分为D1菌株接种组、D2菌株接种组和未接种组。在接种后3、4和5周，比较三组脾脏淋巴细胞对PHA、ConA和PPD刺激的淋巴细胞转化反应。结果表明，接种D2菌株的豚鼠脾脏淋巴细胞对PHA、ConA和PPD刺激的增殖反应高于接种D1菌株的豚鼠。免疫淋巴细胞对PHA和ConA的最敏感时间为接种后4周。接种后5周淋巴细胞对PPD的增殖反应高于4周。本研究表明，D2菌株引发细胞介导免疫的能力强于D1菌株。
