Soules M R, Merriggiola M C, Steiner R A, Clifton D K, Toivola B, Bremner W J
Department of Obstetrics and Gynecology, University of Washington, Seattle.
Clin Endocrinol (Oxf). 1994 Jun;40(6):725-31. doi: 10.1111/j.1365-2265.1994.tb02505.x.
In men and male monkeys, a short-term fast has been reported to have a major effect on the reproductive axis. In this study we investigated the effects of a short-term fast (72 hours) on female reproductive hormone secretion and menstrual function.
The study consisted of an admission day (control), three successive fasting days (fast 1, 2 and 3) and a refeeding day (post fast).
Eight normal cycling women, ages 21-35, within 10% of ideal body weight, were fasted for 72 hours during the follicular phase of their menstrual cycle.
On the admission day, the last day of the fast and the day of refeeding, blood samples were collected at 10-minute intervals from 0800 to 2000 h for determination of the LH pulse pattern. Daily determinations of immuno LH, FSH, oestradiol (E) and progesterone (P) were performed throughout the menstrual cycle in which the fast occurred.
Throughout the fasting days, the consistently low serum levels of glucose and insulin confirmed that all the subjects were fasting. However, in spite of profound metabolic changes and a significant loss of weight, the short-term fast did not have discernible effects upon the reproductive hormones studied. Basal mean LH concentrations did not show any significant variation throughout the study period. The mean +/- SEM number of LH pulses was 13.4 +/- 1.5/12 h on the control day, 12.4 +/- 1.2/12 h (NS) on the third day of fasting and 11.0 +/- 1.5/12 h (NS) the day of refeeding. Each woman maintained a physiological pattern of LH, FSH, E and P throughout the menstrual cycle including the LH surge; ultrasound evidence of normal growth of a dominant follicle; and cycle length consistent with previous cycles.
Our results indicate that in spite of profound metabolic changes, a 72-hour fast during the follicular phase does not affect the menstrual cycle of normal cycling women. It appears that the female reproductive axis during this phase of the cycle is more resistant to an acute caloric deprivation than that of men or male monkeys.
据报道，短期禁食对男性和雄性猴子的生殖轴有重大影响。在本研究中，我们调查了短期禁食（72小时）对女性生殖激素分泌和月经功能的影响。
该研究包括入院日（对照）、连续三个禁食日（禁食第1、2和3天）和一个重新进食日（禁食后）。
八名正常月经周期的女性，年龄在21至35岁之间，体重在理想体重的10%以内，在月经周期的卵泡期禁食72小时。
在入院日、禁食的最后一天和重新进食日，从08:00至20:00每隔10分钟采集一次血样，以确定促黄体生成素（LH）脉冲模式。在发生禁食的整个月经周期中，每天测定免疫LH、促卵泡生成素（FSH）、雌二醇（E）和孕酮（P）。
在整个禁食期间，持续低水平的血糖和胰岛素证实所有受试者都在禁食。然而，尽管发生了深刻的代谢变化和体重显著减轻，但短期禁食对所研究的生殖激素没有明显影响。在整个研究期间，基础平均LH浓度没有显示出任何显著变化。LH脉冲的平均±标准误数量在对照日为13.4±1.5/12小时，禁食第三天为12.4±1.2/12小时（无显著性差异），重新进食日为11.0±1.5/12小时（无显著性差异）。每位女性在整个月经周期（包括LH峰）中都维持了LH、FSH、E和P的生理模式；超声显示优势卵泡正常生长；周期长度与以前的周期一致。
我们的结果表明，尽管发生了深刻的代谢变化，但卵泡期的72小时禁食不会影响正常月经周期女性的月经周期。看来，在月经周期的这个阶段，女性生殖轴比男性或雄性猴子的生殖轴对急性热量剥夺更具抵抗力。
