He Y X, He D X, Zhang H Y
Jishuitan Hospital, Beijing.
Zhonghua Fu Chan Ke Za Zhi. 1994 Feb;29(2):97-9, 125.
The concentration of plasma osteocalcin, or bone GLA protein (BGP), alkaline phosphatase (AKP), calcium and phosphate were measured in 142 pregnant women at various stages of pregnancy and postpartum, and also in another 47 healthy non-pregnant women as control. In contrast to the control group, plasma BGP level showed significant increase at second and third trimester (P < 0.01 and P < 0.001 respectively), with the peak level at immediate postpartum period and returned to normal in 5 days. Serum AKP level increased as pregnancy progress, and there was significant difference between the levels at the 3rd trimester and that at non-pregnant status (P < 0.01). This study demonstrated that there was marked bone metabolism changes during pregnancy, and it indicated that osteocalcin might play a role in the regulation of bone metabolism.
对142名处于孕期不同阶段及产后的孕妇，以及另外47名健康非孕女性作为对照，测定了血浆骨钙素（即骨γ-羧基谷氨酸蛋白，BGP）、碱性磷酸酶（AKP）、钙和磷的浓度。与对照组相比，血浆BGP水平在孕中期和孕晚期显著升高（分别为P < 0.01和P < 0.001），在产后即刻达到峰值水平，并在5天内恢复正常。血清AKP水平随妊娠进展而升高，孕晚期水平与非孕状态水平之间存在显著差异（P < 0.01）。本研究表明，孕期存在明显的骨代谢变化，提示骨钙素可能在骨代谢调节中起作用。
